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doi: 10.3389/fmicb.2017.00324 74 LiangZDiNLiLYangD

Thyroid hormone (T3) deficiency in children is associated with growth reduction [172] and studies in mice using knockout models have also shown that linear growth is impaired in thyroid hormone deficient mice [169,173] when levels are normal but the thyroid receptor (TR1 and TR) is mutated [174,175]